Role of relaxin in diastasis of the pubic symphysis peripartum

本文刊于: 《World Journal of Clinical Cases》 2021年第0期

关键词:
Pregnancy Pubicsymphysisseparation Relax

Keywords:
Pregnancy,Pubic symphysis separation,Relaxin,Neonatal weight,Cross-sectional study,Activities of daily living
摘要
     BACKGROUND Separation of the pubic symphysis can occur during the peripartum period. Relaxin(RLX) is a hormone primarily secreted by the corpus luteum that can mediate hemodynamic changes during pregnancy as well as loosen the pelvic ligaments. However, it is unknown whether RLX is associated with peripartum pubic symphysis separation and if the association is affected by other factors.AIM To study the association between RLX and peripartum pubic symphysis separation and evaluate other factors that might affect this association.METHODS We performed a cross-sectional study of pregnant women between April 2019 and January 2020. Baseline demographic characteristics, including gestational age, weight, neonatal weight, delivery mode and duration of the first and second stages of labor, were recorded. The clinical symptoms were used as a screening index during pregnancy, and the patients with pubic symphysis and inguinal pain were examined by color Doppler ultrasonography to determine whether there was pubic symphysis separation. Serum RLX concentrations were evaluated 1 d after delivery using an enzyme-linked immunosorbent assay, and pubic symphysis separation was diagnosed based on postpartum X-ray examination.We used an independent-sample t test to analyze the association between serum RLX levels and peripartum pubic symphysis separation. Multivariate regression analysis was used to evaluate whether the association between RLX and peripartum pubic symphysis separation was confounded by other factors, and the association between RLX and the severity of pubic symphysis separation was also assessed. We used Pearson correlation analysis to determine the factors related to RLX levels as well as the correlation between the degree of pubic symphysis separation and activities of daily living(ADL) and pain.RESULTS A total of 54 women were enrolled in the study, with 15 exhibiting(observational group) and 39 not exhibiting(control group) peripartum pubic symphysis separation. There were no statistically significant differences in terms of maternal age, gestational age, pre-pregnancy weight, weight gain during pregnancy, delivery modes, or duration of the first or second stages of labor between the 2 groups. We did, however, note a statistically significant difference in serum RLX concentrations and neonatal weight between the observational and control groups(122.3 ± 0.7 μg/mL vs 170.4 ± 42.3 μg/mL, P < 0.05; 3676.000 ± 521.725 g vs 3379.487 ± 402.420 g, P < 0.05, respectively). Multivariate regression analyses showed that serum RLX level [odds ratio(OR): 1.022) and neonatal weight(OR: 1.002) were associated with pubic symphysis separation peripartum. The degree of separation of the pubic symphysis was negatively correlated with ADL and positively correlated with pain. There was no statistically significant association between serum RLX levels and the severity of pubic symphysis separation after adjusting for confounding factors.CONCLUSION Serum RLX levels and neonatal weight were associated with the occurrence, but not the severity, of peripartum pubic symphysis separation.

基金项目:
SupportedbyTheScienceandTechnologyDevelopmentPlanofTaian,No.2018NS0203

上一篇:山西省潞州区:孕产妇健康管理有实效
下一篇:TPOAb、HbA1c、PLGF及血脂水平对妊娠期糖尿病孕妇妊娠结局的影响

分享到: 分享Role of relaxin in diastasis of the pubic symphysis peripartum到腾讯微博           收藏
评论排行
公告 
相关期刊文献推荐
相关会议文献推荐
相关硕士文献推荐
相关博士文献推荐